Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control
Identifieur interne : 000983 ( Main/Exploration ); précédent : 000982; suivant : 000984Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control
Auteurs : Gian-Luca Mclelland [Canada] ; Vincent Soubannier [Canada] ; Carol X. Chen [Canada] ; Heidi M. Mcbride [Canada] ; Edward A. Fon [Canada]Source :
- The EMBO Journal [ 0261-4189 ] ; 2014.
English descriptors
- KwdEn :
- Antimycin A (pharmacology), Autophagy (physiology), Biological Transport, GTP Phosphohydrolases (antagonists & inhibitors), GTP Phosphohydrolases (genetics), Genes, Reporter, HeLa Cells, Humans, Lysosomes (physiology), Microtubule-Associated Proteins (antagonists & inhibitors), Microtubule-Associated Proteins (genetics), Mitochondria (physiology), Mitochondrial Proteins (antagonists & inhibitors), Mitochondrial Proteins (genetics), Mitochondrial Proteins (metabolism), Models, Biological, Oxidation-Reduction, Oxidative Stress, Parkinson Disease (genetics), Parkinson Disease (metabolism), Protein Kinases (physiology), Proteolysis, RNA Interference, RNA, Small Interfering (pharmacology), Recombinant Fusion Proteins (metabolism), Transport Vesicles (metabolism), Ubiquitin-Protein Ligases (genetics), Ubiquitin-Protein Ligases (physiology).
- MESH :
- chemical , antagonists & inhibitors : GTP Phosphohydrolases, Microtubule-Associated Proteins, Mitochondrial Proteins.
- chemical , genetics : GTP Phosphohydrolases, Microtubule-Associated Proteins, Mitochondrial Proteins, Ubiquitin-Protein Ligases.
- chemical , metabolism : Mitochondrial Proteins, Recombinant Fusion Proteins.
- chemical , pharmacology : Antimycin A, RNA, Small Interfering.
- genetics : Parkinson Disease.
- metabolism : Parkinson Disease, Transport Vesicles.
- physiology : Autophagy, Lysosomes, Mitochondria, Protein Kinases, Ubiquitin-Protein Ligases.
- Biological Transport, Genes, Reporter, HeLa Cells, Humans, Models, Biological, Oxidation-Reduction, Oxidative Stress, Proteolysis, RNA Interference.
Abstract
Mitochondrial dysfunction has long been associated with Parkinson's disease (PD).
Url:
DOI: 10.1002/embj.201385902
PubMed: 24446486
PubMed Central: 3989637
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000033
- to stream Pmc, to step Curation: 000033
- to stream Pmc, to step Checkpoint: 000432
- to stream PubMed, to step Corpus: 000788
- to stream PubMed, to step Curation: 000788
- to stream PubMed, to step Checkpoint: 000788
- to stream Ncbi, to step Merge: 001666
- to stream Ncbi, to step Curation: 001666
- to stream Ncbi, to step Checkpoint: 001666
- to stream Main, to step Merge: 000985
- to stream Main, to step Curation: 000983
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control</title><author><name sortKey="Mclelland, Gian Luca" sort="Mclelland, Gian Luca" uniqKey="Mclelland G" first="Gian-Luca" last="Mclelland">Gian-Luca Mclelland</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>McGill Parkinson Program, Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University</institution><addr-line>Montreal, QC, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Soubannier, Vincent" sort="Soubannier, Vincent" uniqKey="Soubannier V" first="Vincent" last="Soubannier">Vincent Soubannier</name><affiliation wicri:level="1"><nlm:aff id="au2"><institution>Neuromuscular Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University</institution><addr-line>Montreal, QC, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Carol X" sort="Chen, Carol X" uniqKey="Chen C" first="Carol X" last="Chen">Carol X. Chen</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>McGill Parkinson Program, Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University</institution><addr-line>Montreal, QC, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Mcbride, Heidi M" sort="Mcbride, Heidi M" uniqKey="Mcbride H" first="Heidi M" last="Mcbride">Heidi M. Mcbride</name><affiliation wicri:level="1"><nlm:aff id="au2"><institution>Neuromuscular Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University</institution><addr-line>Montreal, QC, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Fon, Edward A" sort="Fon, Edward A" uniqKey="Fon E" first="Edward A" last="Fon">Edward A. Fon</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>McGill Parkinson Program, Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University</institution><addr-line>Montreal, QC, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24446486</idno><idno type="pmc">3989637</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3989637</idno><idno type="RBID">PMC:3989637</idno><idno type="doi">10.1002/embj.201385902</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000033</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000033</idno><idno type="wicri:Area/Pmc/Curation">000033</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000033</idno><idno type="wicri:Area/Pmc/Checkpoint">000432</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000432</idno><idno type="wicri:source">PubMed</idno><idno type="wicri:Area/PubMed/Corpus">000788</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000788</idno><idno type="wicri:Area/PubMed/Curation">000788</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000788</idno><idno type="wicri:Area/PubMed/Checkpoint">000788</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000788</idno><idno type="wicri:Area/Ncbi/Merge">001666</idno><idno type="wicri:Area/Ncbi/Curation">001666</idno><idno type="wicri:Area/Ncbi/Checkpoint">001666</idno><idno type="wicri:doubleKey">0261-4189:2014:Mclelland G:parkin:and:pink</idno><idno type="wicri:Area/Main/Merge">000985</idno><idno type="wicri:Area/Main/Curation">000983</idno><idno type="wicri:Area/Main/Exploration">000983</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control</title><author><name sortKey="Mclelland, Gian Luca" sort="Mclelland, Gian Luca" uniqKey="Mclelland G" first="Gian-Luca" last="Mclelland">Gian-Luca Mclelland</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>McGill Parkinson Program, Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University</institution><addr-line>Montreal, QC, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Soubannier, Vincent" sort="Soubannier, Vincent" uniqKey="Soubannier V" first="Vincent" last="Soubannier">Vincent Soubannier</name><affiliation wicri:level="1"><nlm:aff id="au2"><institution>Neuromuscular Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University</institution><addr-line>Montreal, QC, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Chen, Carol X" sort="Chen, Carol X" uniqKey="Chen C" first="Carol X" last="Chen">Carol X. Chen</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>McGill Parkinson Program, Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University</institution><addr-line>Montreal, QC, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Mcbride, Heidi M" sort="Mcbride, Heidi M" uniqKey="Mcbride H" first="Heidi M" last="Mcbride">Heidi M. Mcbride</name><affiliation wicri:level="1"><nlm:aff id="au2"><institution>Neuromuscular Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University</institution><addr-line>Montreal, QC, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author><author><name sortKey="Fon, Edward A" sort="Fon, Edward A" uniqKey="Fon E" first="Edward A" last="Fon">Edward A. Fon</name><affiliation wicri:level="1"><nlm:aff id="au1"><institution>McGill Parkinson Program, Department of Neurology and Neurosurgery, Montreal Neurological Institute and Hospital, McGill University</institution><addr-line>Montreal, QC, Canada</addr-line></nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea>Montreal, QC</wicri:regionArea><wicri:noRegion>QC</wicri:noRegion></affiliation></author></analytic><series><title level="j">The EMBO Journal</title><idno type="ISSN">0261-4189</idno><idno type="eISSN">1460-2075</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antimycin A (pharmacology)</term><term>Autophagy (physiology)</term><term>Biological Transport</term><term>GTP Phosphohydrolases (antagonists & inhibitors)</term><term>GTP Phosphohydrolases (genetics)</term><term>Genes, Reporter</term><term>HeLa Cells</term><term>Humans</term><term>Lysosomes (physiology)</term><term>Microtubule-Associated Proteins (antagonists & inhibitors)</term><term>Microtubule-Associated Proteins (genetics)</term><term>Mitochondria (physiology)</term><term>Mitochondrial Proteins (antagonists & inhibitors)</term><term>Mitochondrial Proteins (genetics)</term><term>Mitochondrial Proteins (metabolism)</term><term>Models, Biological</term><term>Oxidation-Reduction</term><term>Oxidative Stress</term><term>Parkinson Disease (genetics)</term><term>Parkinson Disease (metabolism)</term><term>Protein Kinases (physiology)</term><term>Proteolysis</term><term>RNA Interference</term><term>RNA, Small Interfering (pharmacology)</term><term>Recombinant Fusion Proteins (metabolism)</term><term>Transport Vesicles (metabolism)</term><term>Ubiquitin-Protein Ligases (genetics)</term><term>Ubiquitin-Protein Ligases (physiology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="antagonists & inhibitors" xml:lang="en"><term>GTP Phosphohydrolases</term><term>Microtubule-Associated Proteins</term><term>Mitochondrial Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>GTP Phosphohydrolases</term><term>Microtubule-Associated Proteins</term><term>Mitochondrial Proteins</term><term>Ubiquitin-Protein Ligases</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Mitochondrial Proteins</term><term>Recombinant Fusion Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Antimycin A</term><term>RNA, Small Interfering</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Parkinson Disease</term><term>Transport Vesicles</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Autophagy</term><term>Lysosomes</term><term>Mitochondria</term><term>Protein Kinases</term><term>Ubiquitin-Protein Ligases</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Biological Transport</term><term>Genes, Reporter</term><term>HeLa Cells</term><term>Humans</term><term>Models, Biological</term><term>Oxidation-Reduction</term><term>Oxidative Stress</term><term>Proteolysis</term><term>RNA Interference</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Mitochondrial dysfunction has long been associated with Parkinson's disease (PD). <italic>Parkin</italic> and <italic>PINK1</italic>, two genes associated with familial PD, have been implicated in the degradation of depolarized mitochondria via autophagy (mitophagy). Here, we describe the involvement of parkin and PINK1 in a vesicular pathway regulating mitochondrial quality control. This pathway is distinct from canonical mitophagy and is triggered by the generation of oxidative stress from within mitochondria. Wild-type but not PD-linked mutant parkin supports the biogenesis of a population of mitochondria-derived vesicles (MDVs), which bud off mitochondria and contain a specific repertoire of cargo proteins. These MDVs require PINK1 expression and ultimately target to lysosomes for degradation. We hypothesize that loss of this parkin- and PINK1-dependent trafficking mechanism impairs the ability of mitochondria to selectively degrade oxidized and damaged proteins leading, over time, to the mitochondrial dysfunction noted in PD.</p></div></front></TEI><affiliations><list><country><li>Canada</li></country></list><tree><country name="Canada"><noRegion><name sortKey="Mclelland, Gian Luca" sort="Mclelland, Gian Luca" uniqKey="Mclelland G" first="Gian-Luca" last="Mclelland">Gian-Luca Mclelland</name></noRegion><name sortKey="Chen, Carol X" sort="Chen, Carol X" uniqKey="Chen C" first="Carol X" last="Chen">Carol X. Chen</name><name sortKey="Fon, Edward A" sort="Fon, Edward A" uniqKey="Fon E" first="Edward A" last="Fon">Edward A. Fon</name><name sortKey="Mcbride, Heidi M" sort="Mcbride, Heidi M" uniqKey="Mcbride H" first="Heidi M" last="Mcbride">Heidi M. Mcbride</name><name sortKey="Soubannier, Vincent" sort="Soubannier, Vincent" uniqKey="Soubannier V" first="Vincent" last="Soubannier">Vincent Soubannier</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000983 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000983 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:3989637
|texte= Parkin and PINK1 function in a vesicular trafficking pathway regulating mitochondrial quality control
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24446486" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a ParkinsonCanadaV1
| This area was generated with Dilib version V0.6.29. |  |